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Rendering of Escherichia coli in blue and purple.
Bugs as Drugs to Boost Cancer Therapy
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Bugs as Drugs to Boost Cancer Therapy
Bugs as Drugs to Boost Cancer Therapy

Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.

Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.

News & Opinion

A button-mushroom on the tip of a fork.
The Immune System Helps with Digestion
Shelby Bradford, PhD | Jan 17, 2024 | 3 min read
A special type of immune cell aids digestion of chitin, a fiber found in mushrooms and insects.
Decoding the Cellular Secrets of the Endometrium 
Deanna MacNeil, PhD | Jan 16, 2024 | 3 min read
Endometrial organoids and single cell analyses helped uncover the molecular mechanisms of a rare uterine condition.
Advanced Spatial Tools Map Hematopoietic Stem Cell Niches
Niki Spahich, PhD | Jan 15, 2024 | 4 min read
New technologies and archival tissue biopsy samples enable exploration of changes in the bone marrow as people age.
Charting a New Course Through the Injured Brain
Rashmi Shivni | Jan 15, 2024 | 4 min read
A state-of-the-art technique helps scientists map out tissue at the single cell level after a demyelinating brain injury.
Genotoxic Effects of Base and Prime Editing
Kamal Nahas, PhD | Jan 12, 2024 | 5 min read
A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 
Building Nerf Gun Blasters from DNA Bricks
Laura Tran, PhD | Jan 11, 2024 | 3 min read
Researchers ingeniously repurposed DNA to assemble a miniaturized blaster at the molecular level.
The Evolution of Bats’ Super Immunity
Niki Spahich, PhD | Jan 10, 2024 | 4 min read
Researchers generated complete genomes of two important bat species and explored their immune- and cancer-related genes.
Clues in the Coprolites
Hannah Thomasy, PhD | Jan 9, 2024 | 4 min read
Fossilized feces help scientists understand the lives of Puerto Rico’s earliest inhabitants.
Shedding Light on Cell Attachment
Shelby Bradford, PhD | Jan 8, 2024 | 3 min read
Cell adhesion may be initiated by small proteins previously viewed as helpers, not main players in attachment.
All-nighters Sometimes Combat Depression
Hannah Thomasy, PhD | Jan 5, 2024 | 3 min read
Dopamine pathways play a key role in the surprising effects of sleep deprivation on mood.
The COVID-19 Pandemic Abruptly Altered the Infant Microbiome
Kamal Nahas, PhD | Jan 4, 2024 | 4 min read
Microbial diversity in the infant gut shrank suddenly during the first lockdown, but the lasting health effects are less clear.
Hijacking Neurons’ Adaptive Abilities
Shelby Bradford, PhD | Jan 3, 2024 | 3 min read
Brain tumors use the brain’s plasticity to promote their own growth.
Keeping Kidneys Healthy with a Hand from AI
Aparna Nathan, PhD | Dec 11, 2023 | 3 min read
Researchers found new mechanisms and drug targets for cystinosis.
Addressing Power and Pitfalls in Machine Learning Neoantigen Prediction
Deanna MacNeil, PhD | Dec 11, 2023 | 4 min read
Researchers honed prediction models and datasets to unlock the potential of deep neural networks in biological applications while avoiding bias.
Rodents Offer New Insights Into the Diversity of Addiction
Aparna Nathan, PhD | Dec 1, 2023 | 4 min read
Molecular studies may point to underlying genetics and therapeutic targets.
How Flour Type Affects Sourdough Starters  
Niki Spahich, PhD | Dec 1, 2023 | 4 min read
By studying various sourdough starters and sequencing their microbial menageries, researchers generated useful information for people wanting to experiment in their kitchens and classrooms.
A New mRNA Malaria Vaccine 
Rebecca Roberts, PhD | Nov 30, 2023 | 3 min read
By targeting resident memory T cells in the liver, a novel mRNA malaria vaccine prevented infection, even in those with prior exposure.
Detecting the Viral Elephant in the Room
Laura Tran, PhD | Nov 29, 2023 | 3 min read
A tornado-like vortex sampling technology detects low levels of SARS-CoV-2 viral particles within minutes.
Conceptual retro image of a man wearing a silly mind reading gadget on his head, holding a pencil, and writing his thoughts down in a notebook.
What's Your Story? Ideas and Discoveries Worth Sharing
The Scientist | Nov 29, 2023 | 3 min read
A new writing contest provides life scientists with a platform to try their hands at science journalism, tell their science stories, develop their communication skills, and publish their work.
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