News & Opinion

Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.

A new antibiotic is the first to block a critical transport mechanism in drug-resistant bacteria.

Researchers mapped out cellular changes in the maternal-fetal interface to uncover term and preterm labor complexities.

Clean and dirty mice respond similarly to allergens, challenging the idea that reduced microbial exposure is the primary cause behind the uptick in allergies.

Genes activated in new environments include those used during development.

Not all degenerated intervertebral discs are painful; a new study identified a subset of disc cells that triggers a pathway to pain.

CRISPR-Cas9 editing leads to widespread loss of the targeted chromosome in human T cells, but scientists recently discovered a way to prevent such loss.

A protein’s timely appearance is crucial for Toxoplasma gondii’s unique replication cycle.

A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells. 

Researchers developed a “test tube” so tiny that it can hold a single cell. These vials enabled them to connect protein secretion levels with surface markers and transcriptome data from the same cell. 

A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.

Simulated microgravity in mice reveals a constellation of genes that may influence muscle weakening during spaceflight.

Dietary changes rapidly alter T cell metabolism, but the effects can be reversed.

CD4 T cells mediate gut symptoms that indicate early Parkinson’s disease.

Dorothy Shippen and Borja Barbero Barcenilla investigated how spaceflight affects telomeres of Arabidopsis seedlings grown on the International Space Station.

Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 

Forgetting things appears to be a productive process and not a passive loss of information.

Faced with a lack of consensus in published protocols, researchers found optimal conditions for enhancing cortical neuron adhesion and maturation in culture.

Microbiome studies have yielded hundreds of ideas for ways to detect and influence human health, but the field struggles with reproducibility challenges that hamper bringing these goals to fruition. Identical tubes of fecal matter should help.