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Novelty Activates a Long Noncoding RNA for Spatial Learning in Mice
Shelby Bradford, PhD | Feb 6, 2024 | 4 min read
Genes activated in new environments include those used during development.
Avoiding Gene Editing’s Unintended Consequences
Tanvir Khan, PhD | Feb 2, 2024 | 4 min read
CRISPR-Cas9 editing leads to widespread loss of the targeted chromosome in human T cells, but scientists recently discovered a way to prevent such loss.
Optimizing Gene Editing with PARP1 CRISPR Plasmids
The Scientist and Santa Cruz Biotechnology, Inc. | 3 min read
CRISPR plasmids provide a robust solution for streamlining human cell transfection workflows.
Ferreting Out the Causes of Cystic Fibrosis
Danielle Gerhard, PhD | Feb 1, 2024 | 2 min read
Transgenic ferret models ratted out how a rare cell type affects airway function.
A Master Regulator of Gene Expression
Mariella Bodemeier Loayza Careaga, PhD | Jan 31, 2024 | 4 min read
A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells.
An Overview of High Throughput Screening
Tanvir Khan, PhD | 5 min read
High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, genetic, chemical, or pharmacological samples.
Zero Gravity, Zero Gain: The Genetics Behind Muscle Loss in Space
Kamal Nahas, PhD | Jan 29, 2024 | 4 min read
Simulated microgravity in mice reveals a constellation of genes that may influence muscle weakening during spaceflight.
How Plants Protect Their DNA in Space
Deanna MacNeil, PhD | Jan 24, 2024 | 4 min read
Dorothy Shippen and Borja Barbero Barcenilla investigated how spaceflight affects telomeres of Arabidopsis seedlings grown on the International Space Station.
Hijacking Viruses: Optimizing Lentivirus-Based Cell Engineering
The Scientist | 1 min read
Filippo Rossignoli discusses the challenges he faced when employing lentiviruses to produce immunotherapies and how he overcame these obstacles.
Genotoxic Effects of Base and Prime Editing
Kamal Nahas, PhD | Jan 12, 2024 | 5 min read
A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate.
The Evolution of Bats’ Super Immunity
Niki Spahich, PhD | Jan 10, 2024 | 4 min read
Researchers generated complete genomes of two important bat species and explored their immune- and cancer-related genes.
CRISPR Gene Editing: Cas9 and Beyond
Johanna Pruller, PhD and Deanna MacNeil, PhD | 7 min read
Researchers create and improve CRISPR-Cas mediated gene editing technologies based on prokaryotic CRISPR systems and eukaryotic DNA repair mechanisms.
Clues in the Coprolites
Hannah Thomasy, PhD | Jan 9, 2024 | 4 min read
Fossilized feces help scientists understand the lives of Puerto Rico’s earliest inhabitants.
Breaking Down Barriers to Single-Cell Resolution
The Scientist Staff | Jan 1, 2024 | 2 min read
Microfluidic digital dispensing technology can gently isolate viable and healthy cells suitable for a range of downstream applications.
The Basics and Applications of Cell-Free DNA
Rebecca Roberts, PhD | 5 min read
Found circulating in peripheral blood, scientists use cell-free DNA (cfDNA) to assess genetic abnormalities, infections, cancer, transplant rejection, and cardiovascular disease.
Illuminating Craniofacial Development
Hannah Thomasy, PhD | Jan 1, 2024 | 2 min read
Paul Trainor delves into the genetic and environmental factors that shape the head and face.
The Cre-loxP System: A Powerful Tool in the Genetic Toolbox
Laura Tran, PhD | Dec 4, 2023 | 9 min read
Standing at the cornerstone of genetic research, Cre-loxP recombination serves as molecular scissors for precisely manipulating the genome.
Insights into qPCR: Protocol, Detection Methods, and Analysis
Tanuka Biswas, PhD | 6 min read
Learn about quantitative PCR (qPCR), including its fundamentals, common applications, modes of detection, and key quantification methods.
Infographic: Gene Activity in the Cellular Afterlife
Iris Kulbatski, PhD | Dec 4, 2023 | 3 min read
Low oxygen resuscitates gene transcription after death.
Infographic: Recombinase Polymerase Amplification in Action
Hannah Thomasy, PhD | Dec 4, 2023 | 4 min read
A rapid isothermal amplification technique enables pathogen identification and antibiotic resistance detection in low-resource settings.