T cells

By targeting resident memory T cells in the liver, a novel mRNA malaria vaccine prevented infection, even in those with prior exposure.

Immune receptor repertoire profiling is an important analytic tool for disease research in many areas, including cancer, cell and organ transplantation, autoimmunity, and infectious disease. 

An often overlooked property of the tumor environment shapes T cell function and may improve T cell therapies.

Annie Curtis’s research team revealed how circadian rhythm-regulated mitochondrial metabolism drives dendritic cell antigen presentation activity.

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

Male patients who recover from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges than female patients.

New research may make immunotherapy possible for hard-to-treat brain tumors.

Susan Thomas discusses how her team engineered a microfluidic device to screen for T cells with improved homing capability to tumor cells. 

Males recovered from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges.

A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.

Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.

Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.

Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination.