RNA interference

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

Scarab beetle horns share a common genetic origin with wings.

Alnylam’s patisiran interferes with the production of a mutated protein present in people with hereditary transthyretin amyloidosis.

If approved, patisiran will be the first RNAi therapeutic on the market. 

Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.

High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.

A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 

Plants have so much to teach us.

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.

Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.

Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.

A chance discovery results in the first report of DNA-based gene silencing in an animal.

Early analysis of TKM-Ebola-Guinea offers discouraging results, causing sponsors to end the Phase 2 trial.

RNA interference is proving to be a valuable tool for agriculture, allowing researchers to develop pathogen-resistant and more-nutritious crops.

Now showing clinical progress against liver diseases, the gene-silencing technique begins to fulfill some of its promises.

Assistant Professor, Arizona State University. Age: 36

The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.

Previously enigmatic circular RNAs have been found to influence gene expression by binding to and blocking another class of regulatory RNA, the microRNAs.