mouse study

A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.

Abnormal sympathetic neuron growth leads to simultaneous activation of clusters of sensory neurons, causing the difficult-to-treat sensation.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

While exploring suspended animation in mice, scientists discover how an enzyme can protect the brain from dangerously low levels of oxygen.

Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.

A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.

In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.

Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.

The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Researchers are using experiments and observational studies to look for host genetic variation that could be partly determined by the gut microbiota.

Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

Human stem cells injected into early monkey embryos proliferate and contribute to multiple cell lineages over 20 days of embryonic development.

Corticosterone interferes with signaling in the skin that normally activates hair follicle stem cells, possibly explaining the link between stress and hair loss.

A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.

Altered gut microbiome composition in obese mice and human patients is linked with severity of disease after bone marrow transplantation, a study found.