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New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
gene editing
Ten Years of CRISPR
Sophie Fessl, PhD | Jun 28, 2022 | 7 min read
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
Infographic: Two Guide RNAs Make for Large, Stable Insertions
Dan Robitzski | Jun 13, 2022 | 1 min read
A new technique goes beyond CRISPR and writes two complementary strands of DNA directly into the genome.
Technique Talk: CRISPR for Genome Engineering in Drosophila
The Scientist | 1 min read
Discover how CRISPR is revolutionizing gene editing in a classic genetics research model.
With Two RNA Guides, Editing Technique Writes Long DNA Insertions
Dan Robitzski | Jun 13, 2022 | 3 min read
The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.
Injecting Cockroaches with CRISPR Gene Edits Their Offspring
Sophie Fessl, PhD | May 25, 2022 | 4 min read
A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.
The Scientist Speaks - Homing in on New Anticancer Targets
Sejal Davla, PhD | 1 min read
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa, PhD | May 20, 2022 | 4 min read
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
Researchers Discover What Attracts Mosquitoes to Humans
Sophie Fessl, PhD | May 11, 2022 | 5 min read
A brain area of Aedes aegypti responds specifically to components of human sebum, a study finds.
Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology
The Scientist | 1 min read
Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa, PhD | Mar 2, 2022 | 3 min read
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
CRISPR Patent Ruling Favors Broad Institute
Jef Akst | Mar 1, 2022 | 3 min read
The US Patent and Trademark Office has once again decided that the institute has priority over the University of California and collaborators regarding intellectual property rights for CRISPR-Cas9 gene editing in eukaryotes. But the fight over the technique isn’t over.
Technique Talk: Supporting Organoid Growth in 3D Cell Culture
The Scientist Creative Services Team in collaboration with Bio-Techne | 1 min read
In this workshop, you will learn how to optimally culture organoids and support their growth after genetic manipulation.
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox, PhD | Dec 1, 2021 | 10 min read
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Infographic: RNA Editing Approaches
Christie Wilcox, PhD | Dec 1, 2021 | 1 min read
RNA editing platforms leverage the natural activity of ADAR enzymes to make key changes to messenger RNAs before they are translated into proteins.
A Revolution in Evolution: Rapid, High-Throughput Biochemical Discovery at the Push of a Button
The Scientist Creative Services Team in collaboration with InScripta | 1 min read
Tyson Shepherd will present data from two large-scale screens of libraries developed using the Inscripta Onyx platform.
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021 | 4 min read
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
From Bench to Boardroom
Aparna Nathan, PhD | Oct 25, 2021 | 5 min read
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
The Next Generation of CRISPR-Cas Systems
Nathan Ni, PhD | 1 min read
Researchers reinvent genome editing with new CRISPR-Cas systems.
Researchers Uncover New Families of Gene-Editing Enzymes
Annie Melchor | Sep 15, 2021 | 2 min read
The results reveal evolutionary relatives of the Cas9 enzyme now used extensively in biotechnology.