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drug discovery

Don Ingber engineered cystic fibrosis airway chips that recapitulate patient symptoms.

A New Model of Lung Disease Paves the Way for Personalized Treatments

Nele Haelterman, PhD | May 9, 2022 | 4 min read

Scientists engineered a lung-on-a-chip model from patient cells that mimics cystic fibrosis.

Zebrafish with fluorescent nervous system in green.

Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

Natalia Mesa, PhD | Mar 15, 2022 | 7 min read

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

An Overview of High Throughput Screening

Tanvir Khan, PhD | 5 min read

High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, genetic, chemical, or pharmacological samples.

Ophthamologist Alan Scott Dies at Age 89

Chloe Tenn | Dec 29, 2021 | 2 min read

The Smith-Kettlewell Eye Research Institute scientist developed Botox for medicinal use.

images related to COVID-19 pandemic, including sign reading "please keep your distance," illustration of the virus, various pills, vaccine syringes

What We Learned About COVID-19 in 2021

Shawna Williams | Dec 16, 2021 | 3 min read

As Omicron induces a sense of deja vu at the close of the year, we look back at a few key ways in which our understanding has moved forward.

3D rendered illustration of the human gastrointestinal tract with an inset close up of the epithelium.

Exploring Preclinical Models for Inflammatory Bowel Disease

The Scientist and Altis Biosystems | 4 min read

Learn how epithelial monolayer models help researchers discover effective therapies and biomarkers for inflammatory bowel diseases.

illustration of brain cells in blue with amyloid plaques in orange and pink immune cells

Excerpt from The Memory Thief

Lauren Aguirre | Jun 1, 2021 | 10+ min read

Author Lauren Aguirre finds reasons for optimism in the fight against Alzheimer’s disease.

How the Pharma Industry Pulled Off the Pivot to COVID-19

Diana Kwon | Jul 13, 2020 | 9 min read

The urgent need for tests and therapeutics has brought companies together and pushed researchers to work at breakneck speeds.

How to Speed Up Cell Therapy Development Processes

The Scientist | 1 min read

In this webinar, Patrick Schmidt will explore how to streamline CAR T cell product manufacturing processes for immunotherapy.

Gene Therapy Finds a Fertile Home in Ohio

Shawna Williams | Jan 13, 2020 | 8 min read

The midwestern state has quietly laid the groundwork for a biotech hub.

Scripps Acquires Pfizer’s Massive Microbial Library

Jef Akst | Jan 9, 2020 | 5 min read

The East Coast campus of the research institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products.

Introducing GMP-Grade Recombinant Cytokines for Stem Cell Research

The Scientist and Sino Biological | 3 min read

Cutting edge technology delivers cytokines with high purity, high bioactivity, high batch-to-batch consistency, and high stability.

Artificial Intelligence Shakes Up Drug Discovery

Bianca Nogrady | May 1, 2019 | 8 min read

The pharmaceutical industry is looking to machine learning to overcome complex challenges in drug development.

small-molecule therapeutics treat cancer and other diseases

Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs

Claire Asher | Apr 1, 2019 | 9 min read

Renewed interest from the biotech industry sparks hope for drugging the nucleic acid to treat cancer and other conditions.

Affinity versus Avidity: Differentiating Between Binding Phenomena

The Scientist | 1 min read

In this webinar, Tim Heiseler will discuss the importance of assay design when measuring binding kinetics and affinity values, as well as strategies to mitigate avidity effects.