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Chromosome with gold band
Immunity Genes May Play a Role in Down Syndrome
Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.
Immunity Genes May Play a Role in Down Syndrome
Immunity Genes May Play a Role in Down Syndrome

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

CRISPR

A transverse section of stem wood from the researchers’ greenhouse-grown poplar tree.
CRISPR Trees Could Improve Paper Production
Alejandra Manjarrez, PhD | Aug 15, 2023 | 3 min read
Researchers edited several tree genes to improve suitability and sustainability in the pulp and paper industry.
Photo of Rosa Bacchetta, associate professor of pediatrics at Stanford University
The Future of Gene Therapy for a Rare Pediatric Autoimmune Disease
Niki Spahich, PhD | Jul 10, 2023 | 3 min read
By editing a mutated immune regulatory gene in patient cells, Rosa Bacchetta brings hope to those suffering from IPEX syndrome.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist and Mirus Bio | 3 min read
A high efficiency, low toxicity method for direct RNA delivery into cells.
Illustration of glowing fireflies
Glow-in-the-dark Diagnostics
Danielle Gerhard, PhD | Jul 5, 2023 | 2 min read
A nucleic acid detection platform that marries CRISPR diagnostic tools with bioluminescence could accelerate treatment decisions in the clinic.
Glowing red DNA on bluish background
Redesigning Medicine Using Synthetic Biology
Alison Halliday, PhD, Technology Networks | Jun 21, 2023 | 5 min read
Drawing inspiration from nature, synthetic biology offers exciting opportunities to transform the future of medicine.
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist | 1 min read
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
mosquito on leaf
Combating Mosquito-Borne Diseases with CRISPR
Niki Spahich, PhD | Jun 1, 2023 | 4 min read
As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.
Scientist pipetting at the bench in white coat and purple gloves
Chek-Mate for Gliomas
Aparna Nathan, PhD | May 22, 2023 | 3 min read
New research may make immunotherapy possible for hard-to-treat brain tumors.
Challenges and Applications
Combinatorial Single Cell CRISPR Screens: Challenges and Applications
The Scientist Creative Services Team in collaboration with 10x Genomics | 2 min read
An expert panel will discuss how single cell sequencing enhances throughput in CRISPR gene editing applications.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Editing genome stock photo
Resolving Discrepancies in Mouse and Human Autoimmunity Studies
Niki Spahich, PhD | May 15, 2023 | 4 min read
By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.
Learn how to design an efficient custom CRISPR screen
Designing CRISPR Screens for Efficient Gene Function Analysis
The Scientist and Twist Bioscience | 1 min read
Discover tips and tricks to successfully perform custom CRISPR screens.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
CRISPR for Genome Engineering in Drosophila
Technique Talk: CRISPR for Genome Engineering in Drosophila
The Scientist | 1 min read
Discover how CRISPR is revolutionizing gene editing in a classic genetics research model.
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins.&nbsp;
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.
A normal human liver organoid (left) stained with blue and red next to a fatty liver organoid (right) with lipid droplets stained yellow.
Working Together to Battle Fatty Liver Disorders
Niki Spahich, PhD | Mar 24, 2023 | 6 min read
Benedetta Artegiani and Delilah Hendriks formed a joint laboratory group to understand disease mechanisms and treatments through organoid models.
800-x-560-sept-tss
The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | 1 min read
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
Katherine Irving | Feb 17, 2023 | 5 min read
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
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