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cell biology

Two hands cut and manipulate the genome surrounded by different organs of interest.
The Cre-loxP System: A Powerful Tool in the Genetic Toolbox
Laura Tran, PhD | Dec 4, 2023 | 9 min read
Standing at the cornerstone of genetic research, Cre-loxP recombination serves as molecular scissors for precisely manipulating the genome.
Infographic showing placenta development
Infographic: Early Placenta Development Sets the Stage
Danielle Gerhard, PhD | Dec 4, 2023 | 2 min read
During early pregnancy, the placenta remodels the uterine environment to support fetal growth
Modeling Human Disease and Development with Organoids
Modeling Human Disease and Development with Organoids
The Scientist | 1 min read
Discover how scientists use cardiac and skin organoids to study differentiation and toxicity. 
Infographic showing the multifaceted role of mitochondria
Infographic: Mitochondria, the Cellular Processors
Danielle Gerhard, PhD | Dec 4, 2023 | 1 min read
Following decades of being called “the powerhouse of the cell,” researchers recently proposed a new description that reflects the multifaceted roles of mitochondria.
Illustration of scientists collaborating
When Scientists Collaborate, Science Progresses
Meenakshi Prabhune, PhD | Dec 4, 2023 | 3 min read
Behind every successful scientist, there is another scientist.
Discover the Freshness of Frozen PBMCs
Discover the Freshness of Frozen PBMCs
The Scientist | 1 min read
Researchers discuss how peripheral blood mononuclear cell (PBMC) cryopreservation affects T cell activation and immune cell phenotypes.
DNA spiral with a human face
Infographic: Gene Activity in the Cellular Afterlife   
Iris Kulbatski, PhD | Dec 4, 2023 | 3 min read
Low oxygen resuscitates gene transcription after death.
Infographic showing the breeding schematic to generate Cre-loxP tissue-specific knockout mice.
Infographic: The Cre-lox System Explained
Laura Tran, PhD | Dec 4, 2023 | 1 min read
The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice.
Sino Biological 
Introducing GMP-Grade Recombinant Cytokines for Stem Cell Research
The Scientist and Sino Biological | 3 min read
Cutting edge technology delivers cytokines with high purity, high bioactivity, high batch-to-batch consistency, and high stability.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Infographic showing how some species undergo DNA elimination
Infographic: Programmed DNA Elimination
Aparna Nathan, PhD | Dec 4, 2023 | 3 min read
Removing parts of the genome is a key step in some species’ development.
A microscopy image of an apical-out colon organoid that was produced using MilliporeSigma’s protocol.
Turning Organoids Inside Out 
The Scientist, MilliporeSigma, and Hub Organoids | 4 min read
Discover how a new procedure reverses the polarity of typical basolateral-out organoids to form versatile apical-out organoids.
3d rendered medically accurate illustration of a human embryo anatomy
The Ephemeral Life of the Placenta
Danielle Gerhard, PhD | Dec 4, 2023 | 10+ min read
Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.
Cross-section of a blue and purple mitochondrion.
Rebranding Mitochondria
Danielle Gerhard, PhD | Dec 4, 2023 | 4 min read
As scientists realize the multifaceted role of mitochondria, some feel that the “powerhouse of the cell” analogy is out of date.
A 3D rendering of an albumin’s protein structure.
Providing Stability In Vivo, In Vitro, and In Culture
The Scientist and MilliporeSigma | 3 min read
Albumins enable researchers to bind, sequester, and stabilize important molecules across research applications.
Engineered RNA Export From Living Cells
Danielle Gerhard, PhD | Dec 1, 2023 | 1 min read
A nondestructive approach for packaging, exporting, and delivering RNA provides a glimpse into the dynamic lives of cells.
Image of pancreatic organoids under a microscope with immunofluorescent staining
Pancreatic Organoids Take the Stage
Laura Tran, PhD | Dec 1, 2023 | 2 min read
Meritxell Huch tackled her pipedream of growing three-dimensional pancreatic tissue in a dish.
A 96-well plate with wells spelling out “ANIMAL COMPONENT FREE”.  
Animal Component-Free Reagents Unleash Cell Culture’s True Potential 
The Scientist and MilliporeSigma | 3 min read
The latest synthetic and chemical reagents offer researchers more flexibility, stability, and consistency when working with their cells.
Cartoon illustration of John Gonzalez eating food and questioning if it is chicken
Why Does Everything Taste Like Chicken? 
Laura Tran, PhD | Dec 1, 2023 | 2 min read
With an appetite for answers, scientists get to the meat of why some unusual foods taste like our favorite fowl.
A white brain with clock hands rests in the middle of two scenes of two different times of day, nighttime, indicated by stars on a blue background, is on the left and day, indicated by light blue clouds, on the right.
Sleep Rhythms Prompt Long-term Memories
Shelby Bradford, PhD | Dec 1, 2023 | 2 min read
A bridge between neurons triggers longer, deeper sleep and memory formation in fly larvae.
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